The transcription factors STAT1 and STAT3 appear to play opposite role in tumorigenesis. While STAT3 propmotes survival/proliferation, motility and immune tolerance and is considered as an oncogene, STAT1 mostly triggers antiproliferative and pro-apoptotic responses while enhancing anti-tumor immunity. Despite being activated downstream of common cytokine and growth factor receptors, their activation is reciprocally regulated and perturbation in their balanced expression or phosphorylation levels may re-direct cytokine/ growth factor signals from proliferative to apoptotic, or from inflammatory to anti-inflammatory. Here we review the functional canonical and non-canonical effects of STAT1 and STAT3 activation in tumorigenesis and their potential crossregulation mechanisms.

STAT1 and STAT3 in tumorigenesis: A matter of balance

AVALLE, LIDIA;REGIS, GABRIELLA;NOVELLI, Francesco;POLI, Valeria
2012

Abstract

The transcription factors STAT1 and STAT3 appear to play opposite role in tumorigenesis. While STAT3 propmotes survival/proliferation, motility and immune tolerance and is considered as an oncogene, STAT1 mostly triggers antiproliferative and pro-apoptotic responses while enhancing anti-tumor immunity. Despite being activated downstream of common cytokine and growth factor receptors, their activation is reciprocally regulated and perturbation in their balanced expression or phosphorylation levels may re-direct cytokine/ growth factor signals from proliferative to apoptotic, or from inflammatory to anti-inflammatory. Here we review the functional canonical and non-canonical effects of STAT1 and STAT3 activation in tumorigenesis and their potential crossregulation mechanisms.
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http://dx.doi.org/10.4161/jkst.20045
STAT1; STAT3; tumorigenesis; oncogene; tumor suppressor; inflammation; apoptosis; proliferation; survival; metastasis; tumor invasivity; anti-tumor immune response
Avalle L.; Pensa S.; Regis G.; Novelli F.; V Poli
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/110522
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