External and intra-axonal application of Δ9-tetrahydrocannabinol was without effect on impulse conduction in the giant axon of the squid whereas 10−8m 11-hydroxy-Δ9-tetrahydrocannabinol reversibly blocked conduction in this preparation. This pharmacological effect of 11-hydroxy-Δ9-tetrahydrocannabinol compares in some respects with that produced by the intra-axonal injection of ethanol into these fibres.
Comparison of the effects of 9-tetrahydrocannabinol, 11-hydroxy- 9-tetrahydrocannabinol, and ethanol on the electrophysiological activity of the giant axon of the squid
CARBONE, Emilio
1973-01-01
Abstract
External and intra-axonal application of Δ9-tetrahydrocannabinol was without effect on impulse conduction in the giant axon of the squid whereas 10−8m 11-hydroxy-Δ9-tetrahydrocannabinol reversibly blocked conduction in this preparation. This pharmacological effect of 11-hydroxy-Δ9-tetrahydrocannabinol compares in some respects with that produced by the intra-axonal injection of ethanol into these fibres.
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