The mouse is extensively used as a model system to reproducehuman diseases in a mammalian system, and to consequently allow to examine the molecular and pathogenic features of the disease in a context that is as close as possible to the human being. The use of the mouse has been particularly useful in three large areas of experimental pathogenesis: (1) classic monogenic diseases, (2) cancer development and progression and (3) developmental genetics and congenital pathologies. In each of these areas, significant progress has been made in recent years. Here, after a short introduction to the biology of the mouse and its history as a model organism, we summarise the current status of genetic manipulation of the mouse genome, provide an overview of current knowledge and illustrate some recent advancements.

Mice as experimental organisms.

MERLO, Giorgio Roberto;ALTRUDA, Fiorella;POLI, Valeria
2012-01-01

Abstract

The mouse is extensively used as a model system to reproducehuman diseases in a mammalian system, and to consequently allow to examine the molecular and pathogenic features of the disease in a context that is as close as possible to the human being. The use of the mouse has been particularly useful in three large areas of experimental pathogenesis: (1) classic monogenic diseases, (2) cancer development and progression and (3) developmental genetics and congenital pathologies. In each of these areas, significant progress has been made in recent years. Here, after a short introduction to the biology of the mouse and its history as a model organism, we summarise the current status of genetic manipulation of the mouse genome, provide an overview of current knowledge and illustrate some recent advancements.
2012
John Wiley & Sons, Ltd.
1
11
9780470015902
http://www.els.net
modelli animali; malattie genetiche; genoma
Giorgio Merlo; Fiorella Altruda; Valeria Poli
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/111502
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