Two oil-in-water microemulsions with the same oil/water/co-surfactant (isopropylmyristate, water, 1-butanol), but differing in the surfactant (Aerosol OT or egg lecithin) were studied. The additions of butanolic solutions of two drugs at different lipophilicity (menadione and prednisone) to the same mixture of water/oil/surfactant were examined. The ΔH values were substantially similar to those obtained in the absence of any drug, except in the case of menadione which gave less endothermic values in the microemulsion containing lecithin as a surfactant.
Microcalorimetric study of microemulsions as potential drug delivery systems. II. Evaluation of enthalpy in the presence of drugs.
FUBINI, Bice;GASCO, Maria Rosa;GALLARATE, Marina
1989-01-01
Abstract
Two oil-in-water microemulsions with the same oil/water/co-surfactant (isopropylmyristate, water, 1-butanol), but differing in the surfactant (Aerosol OT or egg lecithin) were studied. The additions of butanolic solutions of two drugs at different lipophilicity (menadione and prednisone) to the same mixture of water/oil/surfactant were examined. The ΔH values were substantially similar to those obtained in the absence of any drug, except in the case of menadione which gave less endothermic values in the microemulsion containing lecithin as a surfactant.
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