The present study was undertaken to determinate whether immunosuppression, induced by perioperative allogenic whole-blood transfusions (AWBTs), adversely affects prognosis after total resection of laryngeal cancer by promoting the appearance of recurrences. We studied 62 patients, aged 37-82 years with TNM stage III and IV (UICC, 1987) laryngeal cancer treated between 1977 and 1983. AWBTs were administered to 30/62 patients perioperatively. All patients were followed up for 4 years. After 4 years we found the following disease-free survival indexes: transfused, 12/30 (40%); nontransfused, 22/32 (70%; p less than 0.05). On the base of these dates, we conclude that AWBTs exert a significant influence on early recurrence and on survival in patients with laryngeal cancer.

Influence of perioperative transfusion therapy on the recurrence potential of locally advanced laryngeal carcinoma. / Bongioannini G;Vercellino M;Rugiu MG;Ferreri A;Succo G;Cortesina G. - In: ORL. - ISSN 0301-1569. - 52(1990), pp. 260-264.

Influence of perioperative transfusion therapy on the recurrence potential of locally advanced laryngeal carcinoma.

SUCCO, Giovanni;CORTESINA, Giorgio
1990

Abstract

The present study was undertaken to determinate whether immunosuppression, induced by perioperative allogenic whole-blood transfusions (AWBTs), adversely affects prognosis after total resection of laryngeal cancer by promoting the appearance of recurrences. We studied 62 patients, aged 37-82 years with TNM stage III and IV (UICC, 1987) laryngeal cancer treated between 1977 and 1983. AWBTs were administered to 30/62 patients perioperatively. All patients were followed up for 4 years. After 4 years we found the following disease-free survival indexes: transfused, 12/30 (40%); nontransfused, 22/32 (70%; p less than 0.05). On the base of these dates, we conclude that AWBTs exert a significant influence on early recurrence and on survival in patients with laryngeal cancer.
ORL
52
260
264
Bongioannini G;Vercellino M;Rugiu MG;Ferreri A;Succo G;Cortesina G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/117197
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