Solitary amyloid tumor of the breast

Primary breast amyloidosis is uncommon and the solitary amyloid tumor of the breast is rarely mentioned in literature. We report the clinical history of a woman presenting with mammograms an area of clustered microcalcifications, with irregular and pleomorphic morphology, mimicking the onset of a cancer. The core biopsy specimens resulting in breast amyloidosis were in disagreement with the radiological Breast Imaging Reporting and Data System (BI-RADS) risk, category 4. Moreover, specimens from abdominal subcutaneous fat and bone marrow biopsies showed no evidence of deposition of amyloid material, allowing exclusion of a systemic disease. Because it is reported the frequent association between breast amyloidosis and malignant lesions, a surgical excision of the microcalcifications was performed. Final histology confirmed the benign nature of the lesion consisting in a solitary amyloid tumor of the breast. This case stresses the importance of multidisciplinary collaboration between Radiologists, Surgeons and Pathologists to achieve a correct diagnosis and treatment of this rare breast disease.