The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition of anaplastic large cell lymphoma and highlighted the need for a further stratification of T-cell neoplasia. Likewise the detection of anaplastic lymphoma kinase (ALK) genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients.

ALK Signaling and Target Therapy in Anaplastic Large Cell Lymphoma

Barreca A;Piva R;Inghirami G;Riccardo Bruna
Membro del Collaboration Group
;
Daniele Corino
Membro del Collaboration Group
;
Ramona Crescenzo
Membro del Collaboration Group
;
Giuditta Cuccuru
Membro del Collaboration Group
;
Filomena di Giacomo
Membro del Collaboration Group
;
Marco Ladetto
Membro del Collaboration Group
;
Indira Landra
Membro del Collaboration Group
;
Enzo Medico
Membro del Collaboration Group
;
Elisa Pellegrino
Membro del Collaboration Group
;
Maria Todaro
Membro del Collaboration Group
;
Paola Campisi
Membro del Collaboration Group
;
2012-01-01

Abstract

The discovery by Morris et al. (1994) of the genes contributing to the t(2;5)(p23;q35) translocation has laid the foundation for a molecular based recognition of anaplastic large cell lymphoma and highlighted the need for a further stratification of T-cell neoplasia. Likewise the detection of anaplastic lymphoma kinase (ALK) genetic lesions among many human cancers has defined unique subsets of cancer patients, providing new opportunities for innovative therapeutic interventions. The objective of this review is to appraise the molecular mechanisms driving ALK-mediated transformation, and to maintain the neoplastic phenotype. The understanding of these events will allow the design and implementation of novel tailored strategies for a well-defined subset of cancer patients.
2012
2
41_1
41_12
Tabbó F; Barreca A; Piva R; Inghirami G; The European T-Cell Lymphoma Study Group; including; Riccardo Bruna; Daniele Corino; Diego Cortese; Ramona C...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/117875
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