Molecular Interaction Fields (MIFs) based descriptors can be conveniently used to characterize and compare chromatographic scales. In this study, Quantitative Structure–Retention Relationships (QSRR) for eight different chromatographic systems were obtained with VolSurf+ descriptors and Partial Least Squares (PLS). A new and purpose-designed analysis tool highlights the different balance of intermolecular interactions governing solute retention, and estimates the similarity between chromatographic systems.

Molecular interaction fields based descriptors to interpret and compare chromatographic indexes

ERMONDI, Giuseppe;CARON, Giulia
2012-01-01

Abstract

Molecular Interaction Fields (MIFs) based descriptors can be conveniently used to characterize and compare chromatographic scales. In this study, Quantitative Structure–Retention Relationships (QSRR) for eight different chromatographic systems were obtained with VolSurf+ descriptors and Partial Least Squares (PLS). A new and purpose-designed analysis tool highlights the different balance of intermolecular interactions governing solute retention, and estimates the similarity between chromatographic systems.
2012
1252
84
89
Chromatographic index, Log k, Molecular interaction fields, PLS, VolSurf+
Giuseppe Ermondi; Giulia Caron
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/121445
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