Leukocyte telomere length (LTL) provides a potential marker of biological age, closely related to the endothelial dysfunction and consequently to the atherosclerotic process. To investigate the relationship between the LTL and the risk of premature acute myocardial infarction and to evaluate the predictive value of LTL on the onset of major cardiovascular events, 199 patients from 18 to 48 years old with first diagnosis of acute myocardial infarction were enrolled and were matched with 190 controls for sex and age (61 year). Clinical data and coronary artery disease were evaluated at enrollment and at follow up. LTL was measured at enrollment using a quantitative PCR-based method. No significant differences were observed in LTL between cases and controls (p = 0.20) and with the presence of coronary artery disease in patients (p = 0.47). Hypercholesterolemic cases presented LTL significantly longer than cases without hypercholesterolemia (t/s: 0.8260.16 p = 0.79 and t/s norm: 0.7960.19 p = 0.01), as confirmed in multivariate regression analysis (p = 0.005, b = 0.09). Furthermore, multivariate regression analysis showed LTL significantly shorter in hypertensive cases than in normotensive cases (p = 0.04, b =20.07). One hundred seventy-one cases (86%) ended the average follow up of 965 years, 92 (54%) presented a major cardiovascular event. At multivariate regression analysis the LTL detected at enrollment did not represent a predictive factor of major cardiovascular events nor it significantly impacted with cumulative events. Based on present cohort of young Italian patients, the LTL did not represent a marker of acute myocardial infarction nor had a predictive role at medium term follow up.

Telomere Length Variation in Juvenile Acute Myocardial Infarction.

RUSSO, ALESSIA;FORNENGO, Cristina;DI GAETANO, Cornelia;RICCERI, FULVIO;GUARRERA, Simonetta;CRITELLI, ROSSANA;ANSELMINO, Matteo;PIAZZA, Alberto;GAITA, Fiorenzo;MATULLO, Giuseppe
2012

Abstract

Leukocyte telomere length (LTL) provides a potential marker of biological age, closely related to the endothelial dysfunction and consequently to the atherosclerotic process. To investigate the relationship between the LTL and the risk of premature acute myocardial infarction and to evaluate the predictive value of LTL on the onset of major cardiovascular events, 199 patients from 18 to 48 years old with first diagnosis of acute myocardial infarction were enrolled and were matched with 190 controls for sex and age (61 year). Clinical data and coronary artery disease were evaluated at enrollment and at follow up. LTL was measured at enrollment using a quantitative PCR-based method. No significant differences were observed in LTL between cases and controls (p = 0.20) and with the presence of coronary artery disease in patients (p = 0.47). Hypercholesterolemic cases presented LTL significantly longer than cases without hypercholesterolemia (t/s: 0.8260.16 p = 0.79 and t/s norm: 0.7960.19 p = 0.01), as confirmed in multivariate regression analysis (p = 0.005, b = 0.09). Furthermore, multivariate regression analysis showed LTL significantly shorter in hypertensive cases than in normotensive cases (p = 0.04, b =20.07). One hundred seventy-one cases (86%) ended the average follow up of 965 years, 92 (54%) presented a major cardiovascular event. At multivariate regression analysis the LTL detected at enrollment did not represent a predictive factor of major cardiovascular events nor it significantly impacted with cumulative events. Based on present cohort of young Italian patients, the LTL did not represent a marker of acute myocardial infarction nor had a predictive role at medium term follow up.
7
11
e49206
e49206
http://www.ncbi.nlm.nih.gov/pubmed/23145125
Leukocyte telomere length; LTL; acute myocardial infarction; AMI; young
A. Russo; L. Palumbo; C. Fornengo; C. Di Gaetano; F. Ricceri; S. Guarrera; R. Critelli; M. Anselmino; A. Piazza; F. Gaita; S. Bergerone; G. Matullo
File in questo prodotto:
File Dimensione Formato  
Telomere length variation in juvenile acute myocardial infarction 2012.pdf

accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 174.78 kB
Formato Adobe PDF
174.78 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/122172
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 7
social impact