The occurrence and clinical impact of herpes simplex virus (HSV) were evaluated in 342 bronchoalveolar lavage specimens from 237 patients. HSV-1 and HSV-2 were detected in 32.1% and <1% of patients, respectively. A significant difference of HSV-1 prevalence and load was found in relation to admission to intensive care unit, mechanical ventilation and mortality within 28 days; in particular, a viral load ≥10(5) copies/mL bronchoalveolar lavage fluid was significantly associated with critical features. No association was found with immune status or other characteristics. Nine of 21 (42.9%) cases of ventilator-associated pneumonia were positive for HSV-1, with poor outcome in six.

Clinical impact of HSV-1 detection in the lower respiratory tract from hospitalized adult patients

Costa C;SIDOTI, Francesca;SINESI, Franca;MERLINO, Chiara;Solidoro P;CAVALLO, Rossana
2012

Abstract

The occurrence and clinical impact of herpes simplex virus (HSV) were evaluated in 342 bronchoalveolar lavage specimens from 237 patients. HSV-1 and HSV-2 were detected in 32.1% and <1% of patients, respectively. A significant difference of HSV-1 prevalence and load was found in relation to admission to intensive care unit, mechanical ventilation and mortality within 28 days; in particular, a viral load ≥10(5) copies/mL bronchoalveolar lavage fluid was significantly associated with critical features. No association was found with immune status or other characteristics. Nine of 21 (42.9%) cases of ventilator-associated pneumonia were positive for HSV-1, with poor outcome in six.
18
8
E305
E307
Herpes simplex virus Intensive care unit; Lower respiratory tract; Mechanical ventilation; Ventilator-associated pneumonia
Costa C; Sidoti F; Saldan A; Sinesi F; Balloco C; Mantovani S; Merlino C; Solidoro P; Cavallo R
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/122229
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