Identifying potential risk factors for developing amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder of adult life, characterized by the progressive loss of upper motor neurons in the primary motor cortex and of the spinal and bulbar lower motor neurons. The cause of sporadic cases and of the majority of hereditary cases remains elusive. So far a total of 17 genes or genetic loci of familial ALS have been identified, related to DNA/RNA processing, protein aggregation, membrane trafficking and axonal transport and mitochondrial dysfunction. A large range of environmental factors have also been studied, with inconclusive results, with the possible exception of cigarette smoking. ALS is now considered a complex multifactorial neurodegenerative disorder, but studies analyzing genetic and environmental factors together are still underway.