The recent discovery of activating mutations in the BRAF gene in many cutaneous melanomas led us to screen the genomic sequence of BRAF exons 11 and 15 in a series of 48 intraocular (uveal) melanomas, together with control samples from three cutaneous melanomas and the SK-Mel-28 cell line, which has a BRAF mutation. The same mutation was detected in two-thirds of our cutaneous melanoma samples, but was not present in any uveal melanomas. This finding further underlines the distinction between uveal and cutaneous melanomas, and suggests that BRAF inhibitors are unlikely to benefit patients with uveal melanoma.

Absence of BRAF gene mutations in uveal melanomas in contrast to cutaneous melanomas

DI NICOLANTONIO, Federica;
2003

Abstract

The recent discovery of activating mutations in the BRAF gene in many cutaneous melanomas led us to screen the genomic sequence of BRAF exons 11 and 15 in a series of 48 intraocular (uveal) melanomas, together with control samples from three cutaneous melanomas and the SK-Mel-28 cell line, which has a BRAF mutation. The same mutation was detected in two-thirds of our cutaneous melanoma samples, but was not present in any uveal melanomas. This finding further underlines the distinction between uveal and cutaneous melanomas, and suggests that BRAF inhibitors are unlikely to benefit patients with uveal melanoma.
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http://dx.doi.org/10.1038/sj.bjc.6600919
BRAF; melanoma; cancer mutations; oncogene
Edmunds SC; Cree IA; Di Nicolantonio F; Hungerford JL; Hurren JS; Kelsell DP
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/126934
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