Pre-clinical and clinical evidences show how vascular normalization can represent a novel strategy to enhance the efficacy of and overcome the acquired resistance to anti-angiogenic therapies in cancer. Several mechanisms of tumor vessel normalization have been unveiled. Among them, secreted class 3 semaphorins (Sema3), which regulate axon guidance and angiogenesis, have been recently identified as novel vascular normalizing agents that halt metastatic dissemination by restoring the vascular function. Here, we discuss the different biological functions and mechanisms of action of Sema3 in the context of tumor vascular normalization and their impact on the different cellular components of the tumor microenvironment

Class 3 semaphorins: physiological vascular normalizing agents for anti-cancer therapy

SERINI, Guido;BUSSOLINO, Federico;MAIONE, FEDERICA;GIRAUDO, Enrico
2013-01-01

Abstract

Pre-clinical and clinical evidences show how vascular normalization can represent a novel strategy to enhance the efficacy of and overcome the acquired resistance to anti-angiogenic therapies in cancer. Several mechanisms of tumor vessel normalization have been unveiled. Among them, secreted class 3 semaphorins (Sema3), which regulate axon guidance and angiogenesis, have been recently identified as novel vascular normalizing agents that halt metastatic dissemination by restoring the vascular function. Here, we discuss the different biological functions and mechanisms of action of Sema3 in the context of tumor vascular normalization and their impact on the different cellular components of the tumor microenvironment
2013
273
2
138
155
http://onlinelibrary.wiley.com/doi/10.1111/joim.2013.273.issue-2/issuetoc
tumor vessel normalization; tumor angiogenesis; metastasis; tumor microenvironment; anti-angiogenic therapy
Guido Serini; Federico Bussolino; Federica Maione; Enrico Giraudo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/127268
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