Malignant gliomas, despite aggressive multimodal therapies and adequate supportive care, still maintain poor prognosis. Solid lipid nanoparticles (SLN) are colloidal carriers that could be regarded as a highly flexible platform for brain tumor imaging and therapeutical purposes. In this chapter we will first describe brain tumors characteristics and conventional therapeutical approaches. In the subsequent sections, we will analyze SLN properties, effectiveness, and future perspectives in both imaging and targeted treatment of malignant gliomas.

Solid lipid nanoparticles for brain tumors therapy: State of the art and novel challenges

ZARA, Gian Paolo;PRIANO, LORENZO;MAURO, Alessandro
2009

Abstract

Malignant gliomas, despite aggressive multimodal therapies and adequate supportive care, still maintain poor prognosis. Solid lipid nanoparticles (SLN) are colloidal carriers that could be regarded as a highly flexible platform for brain tumor imaging and therapeutical purposes. In this chapter we will first describe brain tumors characteristics and conventional therapeutical approaches. In the subsequent sections, we will analyze SLN properties, effectiveness, and future perspectives in both imaging and targeted treatment of malignant gliomas.
PROGRESS IN BRAIN RESEARCH
180
193
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Brioschi AM; Calderoni S; Zara GP; Priano L; Gasco MR; Mauro A.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/128166
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