Live attenuated vaccines provide the most consistent protective immunity in experi- mental models of lentivirus infections. In this study we tested the hypothesis that animals infected with a naturally attenuated small ruminant lentivirus field strain of genotype E may control a challenge infection with a virulent strain of the caprine arthritis encephalitis virus (CAEV-CO). Within genotype E, Roccaverano strain has been described as attenuated since decreased arthritic pathological indexes were recorded in Roccaverano-infected animals compared to animals of the same breed infected with genotype B strains. Moreover, under natural conditions, animals double-infected with genotypes B and E appear less prone to develop SRLV-related disease, leading to a putative protective role of Roccaverano strain. Here we present evidence that goats experimentally infected with the avirulent genotype E SRLV-Roccaverano strain control the proviral load of a pathogenic challenge virus (CAEV-CO strain) more efficiently than naı ̈ve animals and appear to limit the spread of histological lesions to the contralateral joints.

Small ruminant lentivirus genotype B and E interaction: Evidences on the role of Roccaverano strain on reducing proviral load of the challenging CAEV strain.

BERTOLOTTI, Luigi;JUGANARU, MARIA MAGDALENA;PROFITI, Margherita;DE MENEGHI, Daniele;PERONA, Giovanni;TURSI, Massimiliano;ROSATI, Sergio
2012

Abstract

Live attenuated vaccines provide the most consistent protective immunity in experi- mental models of lentivirus infections. In this study we tested the hypothesis that animals infected with a naturally attenuated small ruminant lentivirus field strain of genotype E may control a challenge infection with a virulent strain of the caprine arthritis encephalitis virus (CAEV-CO). Within genotype E, Roccaverano strain has been described as attenuated since decreased arthritic pathological indexes were recorded in Roccaverano-infected animals compared to animals of the same breed infected with genotype B strains. Moreover, under natural conditions, animals double-infected with genotypes B and E appear less prone to develop SRLV-related disease, leading to a putative protective role of Roccaverano strain. Here we present evidence that goats experimentally infected with the avirulent genotype E SRLV-Roccaverano strain control the proviral load of a pathogenic challenge virus (CAEV-CO strain) more efficiently than naı ̈ve animals and appear to limit the spread of histological lesions to the contralateral joints.
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Bertolotti L;Reina R;Mazzei M;Preziuso S;Camero M;Carrozza ML;Cavalli A;Juganaru M;Profiti M;De Meneghi D;Perona G;Renzoni G;Tursi M;Bertoni G;Rosati S
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/130369
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