A new melted bioactive system containing gold nanoparticles (AuNPs) was prepared exploiting a post-synthesis thermal treatment that allows one to modify crystal phases and nature, shape and distribution of the gold species in the glass-ceramic matrix as evidenced by UV–visible spectroscopy, transmission electron microscopy and powder X-ray diffraction analysis. In human MG-63 osteoblasts the presence of Au(n+) species caused an increase of lactate dehydrogenase leakage and malonyldialdehyde production, whereas Hench’s Bioglass HAu-600-17 containing only AuNPs did not cause any effect. In addition, HAu-600-17 caused in vitro hydroxyapatite formation and an increase of specific surface area with a controlled release of gold species; this material is then suitable to be used as a model system for the controlled delivery of nanoparticles.

Gold-containing bioactive glasses: a solid-state synthesis to produce alternative biomaterials for bone implantations

AINA, VALENTINA;CERRATO, Giuseppina;MARTRA, Gianmario;BERGANDI, Loredana;COSTAMAGNA, Costanzo;GHIGO, Dario Antonio;
2013

Abstract

A new melted bioactive system containing gold nanoparticles (AuNPs) was prepared exploiting a post-synthesis thermal treatment that allows one to modify crystal phases and nature, shape and distribution of the gold species in the glass-ceramic matrix as evidenced by UV–visible spectroscopy, transmission electron microscopy and powder X-ray diffraction analysis. In human MG-63 osteoblasts the presence of Au(n+) species caused an increase of lactate dehydrogenase leakage and malonyldialdehyde production, whereas Hench’s Bioglass HAu-600-17 containing only AuNPs did not cause any effect. In addition, HAu-600-17 caused in vitro hydroxyapatite formation and an increase of specific surface area with a controlled release of gold species; this material is then suitable to be used as a model system for the controlled delivery of nanoparticles.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
10, 20121040
1
10
http://dx.doi.org/10.1098/rsif.2012.1040
gold-containing bioactive glasses; solid-state synthesis; physico-chemical characterization; human MG-63 osteoblasts
Valentina Aina; Giuseppina Cerrato; Gianmario Martra; Loredana Bergandi; Costanzo Costamagna; Dario Ghigo; Gianluca Malavasi; Gigliola Lusvardi; Ledi Menabue
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/130383
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