C-(2-Benzyloxy)-ethyl-C'-N-tert-butoxycarbonyl-aminomethyl-o-carborane (8), a potentially useful intermediate for BNCT, has been synthesised. This intermediate can be readily functionalised with several biological vectors and MRI contrast agents. In this work intermediate 8 has been functionalised with a palmityl chain for lipophilic targeting and with Gd(III)-DOTAMA-C-6-NH2 as MRI detector. This combination yielded Gd(III)-C-palmitamidomethyl-C'-DOTAMA-C-6-o-carborane (14) as a dual MRI-BNCT agent.

Synthesis of Gd(III)-C-palmitamidomethyl-C-DOTAMA-C6-o-carborane: a new dual agent for innovative MRI/BNCT applications

AIME, Silvio;BARGE, Alessandro;DEAGOSTINO, Annamaria;GOBETTO, Roberto;NERVI, Carlo;PRANDI, Cristina;TOPPINO, Antonio;VENTURELLO, Paolo
2008-01-01

Abstract

C-(2-Benzyloxy)-ethyl-C'-N-tert-butoxycarbonyl-aminomethyl-o-carborane (8), a potentially useful intermediate for BNCT, has been synthesised. This intermediate can be readily functionalised with several biological vectors and MRI contrast agents. In this work intermediate 8 has been functionalised with a palmityl chain for lipophilic targeting and with Gd(III)-DOTAMA-C-6-NH2 as MRI detector. This combination yielded Gd(III)-C-palmitamidomethyl-C'-DOTAMA-C-6-o-carborane (14) as a dual MRI-BNCT agent.
2008
6
4460
4466
Silvio Aime; Alessandro Barge; Antonella Crivello; Annamaria Deagostino; Roberto Gobetto; Carlo Nervi; Cristina Prandi; Antonio Toppino; Paolo Venture...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/131334
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