Cellular labeling. MR visualization of cells has been attained by anchoring negatively charged Gd-loaded nanoparticles at the cellular membrane by a polycationic linker. Each nanoparticle contains approximately 800 Gd-chelates and each cell has been loaded with approximately 5<106 particles. In this way only 15% of the negative charges on the membrane has been used. The method has been validated by confocal microscopy. (Figure Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
A Novel Method of Cellular Labeling: Anchoring MR-Imaging Reporter Particles on the Outer Cell Surface
GIANOLIO, Eliana;LANZARDO, Stefania;AIME, Silvio
2008-01-01
Abstract
Cellular labeling. MR visualization of cells has been attained by anchoring negatively charged Gd-loaded nanoparticles at the cellular membrane by a polycationic linker. Each nanoparticle contains approximately 800 Gd-chelates and each cell has been loaded with approximately 5<106 particles. In this way only 15% of the negative charges on the membrane has been used. The method has been validated by confocal microscopy. (Figure Presented). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
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