Component of intercellular junctions, such as claudin-1, are essential to maintain the integrity of epithelial tissues. p63 is a transcription factor essential for stratification of ectoderm-derived epithelia, and is mutated in human syndromes characterized by ectodermal dysplasia, ectrodactily and cleft palate. In this experimental work we show that claudin-1 is a target of p63 in the developing epidermis, reinforcing the hypothesis that these two molecules might be linked in a commor regulatory pathway critical for the pathogenesis of ectodermal dysplasia.
Claudin-1 is a p63 target gene with a crucial role in epithelial development.
MERLO, Giorgio Roberto;
2008-01-01
Abstract
Component of intercellular junctions, such as claudin-1, are essential to maintain the integrity of epithelial tissues. p63 is a transcription factor essential for stratification of ectoderm-derived epithelia, and is mutated in human syndromes characterized by ectodermal dysplasia, ectrodactily and cleft palate. In this experimental work we show that claudin-1 is a target of p63 in the developing epidermis, reinforcing the hypothesis that these two molecules might be linked in a commor regulatory pathway critical for the pathogenesis of ectodermal dysplasia.
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