Mn(III)-loaded apoferritin is promptly reduced to Mn(II)–apoferritin by the oxidation of L-DOPA to melanin. The process is nicely witnessed by a marked relaxation enhancement of water proton relaxation rate that has been detected both in cultured melanoma cells and in tumor animal models.
Mn loaded apoferritin as an MRI sensor of melanin formation in melanoma cells.
GENINATTI CRICH, Simonetta;ALBERTI, DIEGO;AIME, Silvio
2012-01-01
Abstract
Mn(III)-loaded apoferritin is promptly reduced to Mn(II)–apoferritin by the oxidation of L-DOPA to melanin. The process is nicely witnessed by a marked relaxation enhancement of water proton relaxation rate that has been detected both in cultured melanoma cells and in tumor animal models.
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