The insulin-like growth factor (IGF) signaling system is comprised of the IGF ligands (IGF-1 and IGF-2), the cell surface receptors that mediate the biological effects of the IGFs (IGF-1 receptor (IGF-1R), IGF-2 receptor and the insulin receptor), as well as a family of circulating IGF-binding proteins. Insulin-like growth factors 1 and 2 have a critical physiological role in the growth and development of many tissues, and are also implicated in various pathological conditions, particularly in multiple myeloma (MM).
Phase I study of the anti insulin-like growth factor1 receptor (IGF-1R) monoclonal antibody, AVE1642, as single agent and incombination with bortezomib in patients with relapsed multiple myeloma.
CAVALLO, Federica;BOCCADORO, Mario;
2011-01-01
Abstract
The insulin-like growth factor (IGF) signaling system is comprised of the IGF ligands (IGF-1 and IGF-2), the cell surface receptors that mediate the biological effects of the IGFs (IGF-1 receptor (IGF-1R), IGF-2 receptor and the insulin receptor), as well as a family of circulating IGF-binding proteins. Insulin-like growth factors 1 and 2 have a critical physiological role in the growth and development of many tissues, and are also implicated in various pathological conditions, particularly in multiple myeloma (MM).
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