A review. Bifunctional chelating agents (BFCAs) are mols. which contain two different moieties: a strong metal chelating unit and a reactive functional group. The latter is directed to react with amines, thiols, alcs. or other reactive mols. to form stable covalent bonds while the chelating moiety is able to strongly coordinate a metal ion. In this way, it is possible to label a mol. of interest (e.g. an antibody or a peptide) with a metal or a radioactive metal ion. Of all the ligands reported so far, those based on a polyamine polycarboxylic structure are most efficient and are widely employed for the chelation of metal ions. The resulting metal complexes have found a broad range of applications in chem., biol. and medicine. Diagnostic imaging (MRI, SPECT, PET), mol. imaging, tumor therapy and luminescent materials are only a few examples. The present crit. review gives an overview of the syntheses and most important applications of polyamino polycarboxylic BFCAs (334 refs.).
The synthesis and application of polyamino polycarboxylic bifunctional chelating agents.
BARGE, Alessandro;CRAVOTTO, Giancarlo;
2011-01-01
Abstract
A review. Bifunctional chelating agents (BFCAs) are mols. which contain two different moieties: a strong metal chelating unit and a reactive functional group. The latter is directed to react with amines, thiols, alcs. or other reactive mols. to form stable covalent bonds while the chelating moiety is able to strongly coordinate a metal ion. In this way, it is possible to label a mol. of interest (e.g. an antibody or a peptide) with a metal or a radioactive metal ion. Of all the ligands reported so far, those based on a polyamine polycarboxylic structure are most efficient and are widely employed for the chelation of metal ions. The resulting metal complexes have found a broad range of applications in chem., biol. and medicine. Diagnostic imaging (MRI, SPECT, PET), mol. imaging, tumor therapy and luminescent materials are only a few examples. The present crit. review gives an overview of the syntheses and most important applications of polyamino polycarboxylic BFCAs (334 refs.).
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