The purpose of this cadaveric study was to evaluate the primary stability of a membrane 
(resorbable polyglactin-910/poly-p-dioxanone) for autologous chondrocyte implantation (ACI) inserted by press-fit into defects in the femoral head and acetabulum. The stability of the membrane was evaluated after implantation in a cartilage defect on both sides of the joint in 12 hips in six cadavers. The hip was manually put through a full range of motion for 50 cycles after each lesion had been created and filled, starting with the acetabulum.
The implanted membranes showed stability in 83.3% of the acetabular defects and in 33.3% of the femoral defects after the 50 cycles. After an additional 50 cycles the acetabular membrane showed stability in a total of eight (67%) out of 12 acetabular lesions.
The results indicate that this membrane tissue is potentially stable in cartilage defects of the acetabulum, which may have clinical applications in autologous chondrocyte implantation.

Primary stability of a PGLA/Polydioxanone membrane for potential autologous chondrocyte implantation in the hip joint. A cadaveric study

CROVA, Maurizio;MASSAZZA, Giuseppe
2013-01-01

Abstract

The purpose of this cadaveric study was to evaluate the primary stability of a membrane 
(resorbable polyglactin-910/poly-p-dioxanone) for autologous chondrocyte implantation (ACI) inserted by press-fit into defects in the femoral head and acetabulum. The stability of the membrane was evaluated after implantation in a cartilage defect on both sides of the joint in 12 hips in six cadavers. The hip was manually put through a full range of motion for 50 cycles after each lesion had been created and filled, starting with the acetabulum.
The implanted membranes showed stability in 83.3% of the acetabular defects and in 33.3% of the femoral defects after the 50 cycles. After an additional 50 cycles the acetabular membrane showed stability in a total of eight (67%) out of 12 acetabular lesions.
The results indicate that this membrane tissue is potentially stable in cartilage defects of the acetabulum, which may have clinical applications in autologous chondrocyte implantation.
2013
3
23
337
342
Arthroscopy, Chondrocyte, Hip, Implantation
Fontana A; Bistolfi A; Crova M; Massazza G
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/135436
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 5
social impact