Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.
Rho-GTPases and Statins: A Potential Target and a Potential Therapeutic Tool Against Tumors?
CAMPIA, IVANA;DOUBLIER, Sophie Michelle;ALDIERI, Elisabetta;BOSIA, Amalia;GHIGO, Dario Antonio;RIGANTI, Chiara
2014-01-01
Abstract
Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.
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