Four lidocaine molecular salts of dicarboxylic acids (oxalic, fumaric, malonic, and succinic) were synthesized and characterized by a combined use of X-ray power and single-crystal diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy (FT-IR), and solid-state NMR (H-1 MAS and CRAMPS, and C-13 and N-15 CPMAS); all molecular salts show a dramatic increase in their melting point with respect to both lidocaine and lidocaine hydrochloride, and a higher dissolution rate and thermodynamic solubility in physiological solution with respect to the free base.

Molecular Salts of Anesthetic Lidocaine with Dicarboxylic Acids: Solid-State Properties and a Combined Structural and Spectroscopic Study

CHIEROTTI, Michele Remo;GOBETTO, Roberto
2013-01-01

Abstract

Four lidocaine molecular salts of dicarboxylic acids (oxalic, fumaric, malonic, and succinic) were synthesized and characterized by a combined use of X-ray power and single-crystal diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy (FT-IR), and solid-state NMR (H-1 MAS and CRAMPS, and C-13 and N-15 CPMAS); all molecular salts show a dramatic increase in their melting point with respect to both lidocaine and lidocaine hydrochloride, and a higher dissolution rate and thermodynamic solubility in physiological solution with respect to the free base.
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2564
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http://pubs.acs.org/doi/abs/10.1021/cg400331h
Dario Braga;Laura Chelazzi;Fabrizia Grepioni;Elena Dichiarante;Michele R. Chierotti;Roberto Gobetto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/139735
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