Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R 2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration.
Titolo: | AR2p/R1pRatiometric Procedure to Assess Matrix Metalloproteinase-2 Activity by Magnetic Resonance Imaging | |
Autori Riconosciuti: | ||
Autori: | Valeria Catanzaro;Concetta V. Gringeri;Valeria Menchise;Sergio Padovan;Cinzia Boffa;Walter Dastrù;Linda Chaabane;Giuseppe Digilio;Silvio Aime | |
Data di pubblicazione: | 2013 | |
Abstract: | Parametric MRI: A paramagnetic gadolinium-loaded liposome for the MRI assessment of the activity of matrix metalloproteinase-2 (MMP-2) is described. The assessment relies on a procedure that involves the ratio R 2p/R1p between the transverse and longitudinal paramagnetic contributions to the water proton relaxation rate. This method is independent of the total gadolinium concentration. | |
Volume: | 52 | |
Fascicolo: | 14 | |
Pagina iniziale: | 3926 | |
Pagina finale: | 3930 | |
Digital Object Identifier (DOI): | 10.1002/anie.201209286 | |
Rivista: | ANGEWANDTE CHEMIE. INTERNATIONAL EDITION | |
Appare nelle tipologie: | 03A-Articolo su Rivista |
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