The post-genomic era shifted the main biological focus from ‘single-gene’ to ‘genome-wide’ approaches. High throughput data available from new technologies allowed to get inside main features of gene expression and its regulation and, at the same time, to discover a more complex level of organization. Analysis of this complexity demonstrated the existence of non-random and well-defined structures that determine a network of interactions. In the first part of the chapter we present a functional introduction to mechanisms involved in genes expression regulation, an overview of network theory and main technologies developed in last years to analyze biological processes are discussed. In the second part, we review genes regulatory networks and their importance in system biology.
Introduction to GRNs (gene Regulatory Networks)
ALA, UGO;DAMASCO, CHRISTIAN
2009-01-01
Abstract
The post-genomic era shifted the main biological focus from ‘single-gene’ to ‘genome-wide’ approaches. High throughput data available from new technologies allowed to get inside main features of gene expression and its regulation and, at the same time, to discover a more complex level of organization. Analysis of this complexity demonstrated the existence of non-random and well-defined structures that determine a network of interactions. In the first part of the chapter we present a functional introduction to mechanisms involved in genes expression regulation, an overview of network theory and main technologies developed in last years to analyze biological processes are discussed. In the second part, we review genes regulatory networks and their importance in system biology.
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