We report, in a clinical setting, the tigecycline concentration and area under the concentration-time curve (AUC) - both in blood and in cerebrospinal fluid (CSF) - of a patient with a ventriculo-atrial shunt infection. Tigecycline weakly penetrates CSF the CSF-to-serum concentration ratio was 0.079 and CSF-to-serum AUC0-12 ratio was 0.067.

Cerebrospinal fluid penetration of tigecycline

D'AVOLIO, ANTONIO;DI PERRI, Giovanni;
2014

Abstract

We report, in a clinical setting, the tigecycline concentration and area under the concentration-time curve (AUC) - both in blood and in cerebrospinal fluid (CSF) - of a patient with a ventriculo-atrial shunt infection. Tigecycline weakly penetrates CSF the CSF-to-serum concentration ratio was 0.079 and CSF-to-serum AUC0-12 ratio was 0.067.
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Pallotto C;Fiorio M;D'Avolio A;Sgrelli A;Baldelli F;Di Perri G;De Socio GV
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/141158
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