The importance of linking reagents in drug targeting procedures is reviewed, with particular emphasis on the design of the best chemical procedures used to optimize pharmacokinetic and pharmacodynamic properties. Some molecular conjugates, such as immunotoxins, antibody/drug and albumin/drug conjugates, or particulate conjugates such as immunoliposomes, are discussed in this connection.
Single-step purification of immunotoxins containing a high-anionic charge ribosome-inactivating protein clavin by carboxymethyl high-performance membrane chromatography
DOSIO, Franco;ARPICCO, Silvia Maria;GASTALDI, Daniela
1999-01-01
Abstract
The importance of linking reagents in drug targeting procedures is reviewed, with particular emphasis on the design of the best chemical procedures used to optimize pharmacokinetic and pharmacodynamic properties. Some molecular conjugates, such as immunotoxins, antibody/drug and albumin/drug conjugates, or particulate conjugates such as immunoliposomes, are discussed in this connection.
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