Two Cu-containing bioactive glasses were prepared and characterized in order to obtain a detaileddescription of chemical, morphological and bioactivity proprieties of potential Cu releasing systems. Thecharacterization has demonstrated that by varying the synthesis procedure is possible to obtain two sys-tems with Cu species in two different oxidation states and aggregation: (i) SGCu(ox) – oxidated Cu – (Cuoxidation state +2) homogeneously dispersed in the glass network matrix and (ii) SGCu(red) – metallic Cu– (Cu oxidation state 0) containing nano-particles (5–130 nm range) mainly present on the glass surface.The introduction of Cu maintains the bioactivity of the Cu-containing glasses almost unchanged, inducinga partial delay in the hydroxyapatite/hydroxy-carbonate apatite (HA/HCA) formation on the glass surfacewith respect to the reference glass (free Cu glass). During the bioactivity test, Cu is released from bothCu-containing glasses, in particular in the case of the SGCu(red) the presence of Cu nanoparticles (CuNPs)of diameter in the range 5–10 nm has been detected in solution.

Towards the controlled release of metal nanoparticles frombiomaterials: Physico-chemical, morphological and bioactivityfeatures of Cu-containing sol–gel glasses

AINA, VALENTINA;CERRATO, Giuseppina;MARTRA, Gianmario;
2013

Abstract

Two Cu-containing bioactive glasses were prepared and characterized in order to obtain a detaileddescription of chemical, morphological and bioactivity proprieties of potential Cu releasing systems. Thecharacterization has demonstrated that by varying the synthesis procedure is possible to obtain two sys-tems with Cu species in two different oxidation states and aggregation: (i) SGCu(ox) – oxidated Cu – (Cuoxidation state +2) homogeneously dispersed in the glass network matrix and (ii) SGCu(red) – metallic Cu– (Cu oxidation state 0) containing nano-particles (5–130 nm range) mainly present on the glass surface.The introduction of Cu maintains the bioactivity of the Cu-containing glasses almost unchanged, inducinga partial delay in the hydroxyapatite/hydroxy-carbonate apatite (HA/HCA) formation on the glass surfacewith respect to the reference glass (free Cu glass). During the bioactivity test, Cu is released from bothCu-containing glasses, in particular in the case of the SGCu(red) the presence of Cu nanoparticles (CuNPs)of diameter in the range 5–10 nm has been detected in solution.
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http://ac.els-cdn.com/S0169433213012051/1-s2.0-S0169433213012051-main.pdf?_tid=67d94f06-b3a6-11e5-8493-00000aab0f27&acdnat=1451996479_c5a5ddac5c17210c534aa1f7937410de
Cu-containing glasses; Cu nanoparticles (CuNPs); Cu ions; Physico-chemical characterization; In vitro bioactivity
Valentina Aina; Giuseppina Cerrato; Gianmario Martra; Gianluca Malavasi; Gigliola Lusvardi; Ledi Menabue
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/141621
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