Mutations that activate the small GTP-binding protein KRAS are the most common oncogenic event in human tumors. Thirty years after its discovery, mutant KRAS has yet to be therapeutically conquered.
Climbing RAS, the Everest of Oncogenes.
RUSSO, MARIANGELA;DI NICOLANTONIO, Federica;BARDELLI, Alberto
2014-01-01
Abstract
Mutations that activate the small GTP-binding protein KRAS are the most common oncogenic event in human tumors. Thirty years after its discovery, mutant KRAS has yet to be therapeutically conquered.
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