Catastrophic Antiphospholipid syndrome (CAPS) is a very severe variant of the classic APS, characterised by clinical evidence of multiple organ involvement developing over a very short period of time, histopathological evidence of multiple small vessel occlusions, and laboratory confirmation of the presence of antiphospholipid antibodies (aPL), usually in high titre. Although patients with catastrophic APS represent less than 1% of all patients with APS, this is usually a life-threatening condition. In this article we aimed to review the state-of-the art about current knowledge in pathogenesis, clinical manifestations, diagnosis, and treatment strategies in CAPS.

Catastrophic antiphospholipid syndrome (CAPS).

SCIASCIA, Savino;ROCCATELLO, Dario;
2012-01-01

Abstract

Catastrophic Antiphospholipid syndrome (CAPS) is a very severe variant of the classic APS, characterised by clinical evidence of multiple organ involvement developing over a very short period of time, histopathological evidence of multiple small vessel occlusions, and laboratory confirmation of the presence of antiphospholipid antibodies (aPL), usually in high titre. Although patients with catastrophic APS represent less than 1% of all patients with APS, this is usually a life-threatening condition. In this article we aimed to review the state-of-the art about current knowledge in pathogenesis, clinical manifestations, diagnosis, and treatment strategies in CAPS.
2012
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4
535
541
catastrophic antiphospholipid syndrome; antiphospholipid syndrome; IVIG
Sciascia S;Lopez-Pedrera C;Roccatello D;Cuadrado MJ
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/142466
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