Vascularization is crucial for solid tumour growth and invasion, providing metabolic support and sustaining metastatic dissemination. It is now accepted that ion channels and transporters play a significant role in driving the cancer growth at all stages. They may represent novel therapeutic, diag- nostic and prognostic targets for anti-cancer therapies. On the other hand, although the expression and role of ion channels and transporters in the vas- cular endothelium is well recognized and subject of recent reviews, only recently has their involvement in tumour vascularization been recognized. Here, we review the current literature on ion channels and transporters directly involved in the angiogenic process. Particular interest will be focused on tumour angiogenesis in vivo aswell as in the different steps that drive this process in vitro, such as endothelial cell proliferation, migration, adhesion and tubulogenesis. Moreover, we compare the ‘transportome’ system of tumour vascular network with the physiological one.

Functional properties of ion channels and transporters in tumour vascularization

FIORIO PLA, ALESSANDRA;MUNARON, Luca Maria
2014

Abstract

Vascularization is crucial for solid tumour growth and invasion, providing metabolic support and sustaining metastatic dissemination. It is now accepted that ion channels and transporters play a significant role in driving the cancer growth at all stages. They may represent novel therapeutic, diag- nostic and prognostic targets for anti-cancer therapies. On the other hand, although the expression and role of ion channels and transporters in the vas- cular endothelium is well recognized and subject of recent reviews, only recently has their involvement in tumour vascularization been recognized. Here, we review the current literature on ion channels and transporters directly involved in the angiogenic process. Particular interest will be focused on tumour angiogenesis in vivo aswell as in the different steps that drive this process in vitro, such as endothelial cell proliferation, migration, adhesion and tubulogenesis. Moreover, we compare the ‘transportome’ system of tumour vascular network with the physiological one.
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Fiorio Pla A; Munaron L
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/143024
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