Physicians are often approached by young women with a BRCA mutation and a recent history of breast cancer who wish to have a baby. They wish to know if pregnancy impacts upon their future risks of cancer recurrence and survival. To date, there is little information on the survival experience of women who carry a mutation in one of the BRCA genes and who become pregnant. From an international multi-center cohort study of 12,084 women with a BRCA1 or BRCA2 mutation, we identified 128 case subjects who were diagnosed with breast cancer while pregnant or who became pregnant after a diagnosis of breast cancer. These women were age-matched to 269 mutation carriers with breast cancer who did not become pregnant (controls). Subjects were followed from the date of breast cancer diagnosis until the date of last follow-up or death from breast cancer. The Kaplan-Meier method was used to estimate 15-year survival rates. The hazard ratio for survival associated with pregnancy was calculated using a left-truncated Cox proportional hazard model, adjusting for other prognostic factors. Among women who were diagnosed with breast cancer when pregnant or who became pregnant thereafter, the 15-year survival rate was 91.5 %, compared to a survival of 88.6 % for women who did not become pregnant (adjusted hazard ratio = 0.76; 95 % CI 0.31-1.91; p = 0.56). Pregnancy concurrent with or after a diagnosis of breast cancer does not appear to adversely affect survival among BRCA1/2 mutation carriers.

The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation

PASINI, Barbara;
2013-01-01

Abstract

Physicians are often approached by young women with a BRCA mutation and a recent history of breast cancer who wish to have a baby. They wish to know if pregnancy impacts upon their future risks of cancer recurrence and survival. To date, there is little information on the survival experience of women who carry a mutation in one of the BRCA genes and who become pregnant. From an international multi-center cohort study of 12,084 women with a BRCA1 or BRCA2 mutation, we identified 128 case subjects who were diagnosed with breast cancer while pregnant or who became pregnant after a diagnosis of breast cancer. These women were age-matched to 269 mutation carriers with breast cancer who did not become pregnant (controls). Subjects were followed from the date of breast cancer diagnosis until the date of last follow-up or death from breast cancer. The Kaplan-Meier method was used to estimate 15-year survival rates. The hazard ratio for survival associated with pregnancy was calculated using a left-truncated Cox proportional hazard model, adjusting for other prognostic factors. Among women who were diagnosed with breast cancer when pregnant or who became pregnant thereafter, the 15-year survival rate was 91.5 %, compared to a survival of 88.6 % for women who did not become pregnant (adjusted hazard ratio = 0.76; 95 % CI 0.31-1.91; p = 0.56). Pregnancy concurrent with or after a diagnosis of breast cancer does not appear to adversely affect survival among BRCA1/2 mutation carriers.
2013
142
1
177
185
https://link.springer.com/article/10.1007%2Fs10549-013-2729-1
Breast cancer; BRCA mutations; Pregnancy; Survival
Valentini A; Lubinski J; Byrski T; Ghadirian P; Moller P; Lynch HT; Ainsworth P; Neuhausen SL; Weitzel J; Singer CF; Olopade OI; Saal H; Lyonnet DS; Foulkes WD; Kim-Sing C; Manoukian S; Zakalik D; Armel S; Senter L; Eng C; Grunfeld E; Chiarelli AM; Poll A; Sun P; Narod SA; Hereditary Breast Cancer Clinical Study Group: Gronwald J; Cybulski C; Huzarski T; Robidoux A; Offit K; Gershoni-Baruch R; Isaacs C; Tung N; Rosen B; Demsky R; McCuaig J; Eisen A; Bordeleau L; Karlan B; Garber J; Gilchrist D; Eng C; Couch F; Evans G; Kwong A; Maehle L; Friedman E; McKinnon W; Wood M; Daly M; Blum JL; Robson M; Chudley A; Panchal S; McLennan J; Pasini B; Rennert G; Lunn J; Fallen T; Rayson D; Smith M; Ginsburg O; Lemire E; Meschino W; Vadaparampil S; Euhus D; Costalas JW; Donenberg T; Kurz RN; Friedman S; Sweet K; Cullinane CA; Reilly RE; Kotsopoulos J; Nanda S; Metcalfe K.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/144086
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