Neuroglobin is a brain globin with neuroprotective effects against ischemia and related pathological processes, acting as O2 sensor and antiapoptotic pathway transducer. Here, we survey data on neuroanatomical coexpression of transcription factors, epigenetic signature and predictive transcription factor binding sites at the neuroglobin gene locus to find hints of pathways to neuroglobin transcriptional regulation. These data provide a glimpse of how neuroglobin expression may translate into neuronal diversity and function, as well as disease.

Genomic lens on neuroglobin transcription.

CUTRUPI, SANTINA;FERRERO, GIULIO;REINERI, STEFANIA;CORDERO, Francesca;DE BORTOLI, Michele
2014

Abstract

Neuroglobin is a brain globin with neuroprotective effects against ischemia and related pathological processes, acting as O2 sensor and antiapoptotic pathway transducer. Here, we survey data on neuroanatomical coexpression of transcription factors, epigenetic signature and predictive transcription factor binding sites at the neuroglobin gene locus to find hints of pathways to neuroglobin transcriptional regulation. These data provide a glimpse of how neuroglobin expression may translate into neuronal diversity and function, as well as disease.
IUBMB LIFE
66
1
46
51
http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291521-6551
neuroglobin; bioinformatics; transcriptional regulation
Cutrupi S;Ferrero G;Reineri S;Cordero F;De Bortoli M
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/147592
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