Malignant brain tumours are one of the most relevant causes of morbidity and mortality across a wide range of individuals. Malignant glioma is the most common intra axial tumor in the adult. Many researches on this theme brought advances in the knowledge of gliomas biology and pathogenesis and to the development of new agents for targeted molecular therapy. Recent studies focused on either tumor metabolism analysis or epigenetic regulation in the pathogenesis or maintenance of brain tumors. This Review summarizes these developments analyzing molecular pathology and possible further developments for targeted therapies.

Molecular biology of gliomas: present and future challenges.

ALTIERI, Roberto;AGNOLETTI, Alessandro;Garbossa D;BOZZARO, Marco Marcello;FORNARO, Riccardo;MENCARANI, CAMILLA;LANOTTE, Michele Maria Rosario;DUCATI, Alessandro
2014

Abstract

Malignant brain tumours are one of the most relevant causes of morbidity and mortality across a wide range of individuals. Malignant glioma is the most common intra axial tumor in the adult. Many researches on this theme brought advances in the knowledge of gliomas biology and pathogenesis and to the development of new agents for targeted molecular therapy. Recent studies focused on either tumor metabolism analysis or epigenetic regulation in the pathogenesis or maintenance of brain tumors. This Review summarizes these developments analyzing molecular pathology and possible further developments for targeted therapies.
10
7
29
37
Glioma; genetics; metilation; IDH; therapy
Altieri R; Agnoletti A; Quattrucci F; Garbossa D; Calamo Specchia FM; Bozzaro M; Fornaro R; Mencarani C; Lanotte M; Spaziante R; Ducati A
File in questo prodotto:
File Dimensione Formato  
Trans Med UniSa 2014.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 240.78 kB
Formato Adobe PDF
240.78 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/148176
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact