Malignant brain tumours are one of the most relevant causes of morbidity and mortality across a wide range of individuals. Malignant glioma is the most common intra axial tumor in the adult. Many researches on this theme brought advances in the knowledge of gliomas biology and pathogenesis and to the development of new agents for targeted molecular therapy. Recent studies focused on either tumor metabolism analysis or epigenetic regulation in the pathogenesis or maintenance of brain tumors. This Review summarizes these developments analyzing molecular pathology and possible further developments for targeted therapies.

Molecular biology of gliomas: present and future challenges.

ALTIERI, Roberto;AGNOLETTI, Alessandro;Garbossa D;BOZZARO, Marco Marcello;FORNARO, Riccardo;MENCARANI, CAMILLA;LANOTTE, Michele Maria Rosario;DUCATI, Alessandro
2014-01-01

Abstract

Malignant brain tumours are one of the most relevant causes of morbidity and mortality across a wide range of individuals. Malignant glioma is the most common intra axial tumor in the adult. Many researches on this theme brought advances in the knowledge of gliomas biology and pathogenesis and to the development of new agents for targeted molecular therapy. Recent studies focused on either tumor metabolism analysis or epigenetic regulation in the pathogenesis or maintenance of brain tumors. This Review summarizes these developments analyzing molecular pathology and possible further developments for targeted therapies.
2014
10
7
29
37
Glioma; genetics; metilation; IDH; therapy
Altieri R; Agnoletti A; Quattrucci F; Garbossa D; Calamo Specchia FM; Bozzaro M; Fornaro R; Mencarani C; Lanotte M; Spaziante R; Ducati A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/148176
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