Osteonecrosis of the jaw (ONJ ) was recently described as an adverse side effect of bisphosphonate therapy, but has not been studied in McCune Albright syndrome (MAS). The aim of the study was to search clinical and radiological ONJ signs as possible consequence of intravenous pamidronate treatment in MAS bone fibrous dysplasia (BFD). We enrolled 10 mas patients (4 males and 6 females) with craniofacial and/or long bone BFD; mean age at the evaluation time was 20 years and 4 months (range 7-27 year). All the patients had been treated during pediatric age with pamidronate at dosage of 1mg/kg/day for 3 consecutive days at 4-6 months interval, for more than 30 months. They all underwent clinical and oral evaluation and were investigated by panoramic radiograph and CT imaging. No patient developed ONJ, periodontal disease, or dental anomalies and only two patients showed caries; none of them showed fistula, bone exposure or radiological signs different from those typical of BDF of the jaw (radiolucent cystic area, endosteal scalloping and thinning of the cortex). The major phenotypic expression of MAS was malocclusion (4 patients). Anyway, good oral hygiene, careful dental care and follow-up are highly recommended in this type of patients.

MacCune Albright Syndrome: investigation of negative effects of biphosphonates on jaws

MUSSA, ALESSANDRO;DEFABIANIS, Patrizia
;
2012-01-01

Abstract

Osteonecrosis of the jaw (ONJ ) was recently described as an adverse side effect of bisphosphonate therapy, but has not been studied in McCune Albright syndrome (MAS). The aim of the study was to search clinical and radiological ONJ signs as possible consequence of intravenous pamidronate treatment in MAS bone fibrous dysplasia (BFD). We enrolled 10 mas patients (4 males and 6 females) with craniofacial and/or long bone BFD; mean age at the evaluation time was 20 years and 4 months (range 7-27 year). All the patients had been treated during pediatric age with pamidronate at dosage of 1mg/kg/day for 3 consecutive days at 4-6 months interval, for more than 30 months. They all underwent clinical and oral evaluation and were investigated by panoramic radiograph and CT imaging. No patient developed ONJ, periodontal disease, or dental anomalies and only two patients showed caries; none of them showed fistula, bone exposure or radiological signs different from those typical of BDF of the jaw (radiolucent cystic area, endosteal scalloping and thinning of the cortex). The major phenotypic expression of MAS was malocclusion (4 patients). Anyway, good oral hygiene, careful dental care and follow-up are highly recommended in this type of patients.
2012
150
150
http://www.amazon.it/European-Society-Paediatric-Endocrinology-Espe/dp/3805598351
D.TESSARIS; P.MATARAZZO; A.MUSSA; T. GERLI; F.VERNA; M.TORDELLA; A.CIMMA; P.DEFABIANIS; R.LALA
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/148405
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