A versatile method for assessing protein properties via magnetic resonance imaging (MRI) through chemical exchange saturation transfer (CEST) modality is described. The observed CEST signal changes allow monitoring of protein aggregation processes, protein folding/unfolding steps and interaction with lipid membranes.
Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins' behaviour
LONGO, DARIO LIVIO;DI GREGORIO, ENZA;AIME, Silvio
2014-01-01
Abstract
A versatile method for assessing protein properties via magnetic resonance imaging (MRI) through chemical exchange saturation transfer (CEST) modality is described. The observed CEST signal changes allow monitoring of protein aggregation processes, protein folding/unfolding steps and interaction with lipid membranes.
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