Essential oils of chamomile contain several bioactive compounds, including monoterpenes, sesquiterpenes, triterpenes and fatty acids. Hydrodistillation of chamomile essential oil (EO) induces the formation of chamazulene, a bioactive compound. Chamazulene was isolated from EO by column chromatography. The total antioxidant capacity confirmed a higher antioxidant activity of chamazulene (IC50 = 6.4 µg ml-1), when compared to ascorbic acid (IC50 = 12.8 µg ml-1), α-tocopherol (IC50 = 20.5 µg ml-1), and BHT (IC50 = 30.8 µg ml-1). Chamazulene was unable to react with DPPH●. However, when chamazulene was assayed with ABTS● a strong and significantly (P<0.05) higher free radical scavenging activity was observed (IC50 = 3.7 µg ml-1), with respect to BHT (IC50 = 6.2 µg ml-1) and α-tocopherol (IC50 = 11.5 µg ml-1). The results of this work show that chamazulene is an important factor for the antioxidant power of chamomile oil.

Antioxidant and radical scavenging activities of chamazulene

CAPUZZO, ANDREA;OCCHIPINTI, Andrea;MAFFEI, Massimo Emilio
2014

Abstract

Essential oils of chamomile contain several bioactive compounds, including monoterpenes, sesquiterpenes, triterpenes and fatty acids. Hydrodistillation of chamomile essential oil (EO) induces the formation of chamazulene, a bioactive compound. Chamazulene was isolated from EO by column chromatography. The total antioxidant capacity confirmed a higher antioxidant activity of chamazulene (IC50 = 6.4 µg ml-1), when compared to ascorbic acid (IC50 = 12.8 µg ml-1), α-tocopherol (IC50 = 20.5 µg ml-1), and BHT (IC50 = 30.8 µg ml-1). Chamazulene was unable to react with DPPH●. However, when chamazulene was assayed with ABTS● a strong and significantly (P<0.05) higher free radical scavenging activity was observed (IC50 = 3.7 µg ml-1), with respect to BHT (IC50 = 6.2 µg ml-1) and α-tocopherol (IC50 = 11.5 µg ml-1). The results of this work show that chamazulene is an important factor for the antioxidant power of chamomile oil.
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http://www.tandfonline.com/doi/abs/10.1080/14786419.2014.931393#.VHM7tska7d4
Antioxidant activity; Radical scavenging; chamazulene
Capuzzo, A.; Occhipinti, A.; Maffei, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/149892
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