Semaphorins are extracellular signals known to guide migrating cells during developmental morphogenesis and in adult tissues. Semaphorin receptors, that is plexins and neuropilins, have been found in association with diverse receptor tyrosine kinases (RTKs), such as Met, ErbB2 and VEGFR2. These receptor complexes are formed in a cell-specific manner and can mediate distinctive signalling cascades, sometimes leading to divergent functional outcomes. This is particularly intriguing in cancer, since the same semaphorin has been found to mediate either tumor-promoting or tumor-suppressing functions, depending on the cancer type and cellular context. We will therefore review the current understanding about the role of RTKs in neuropilin and plexin signalling, putatively accounting for the multifaceted role of semaphorins in cancer.

Semaphorin receptors meet receptor tyrosine kinases on the way of tumor progression

CAGNONI, GABRIELLA;TAMAGNONE, Luca
2014-01-01

Abstract

Semaphorins are extracellular signals known to guide migrating cells during developmental morphogenesis and in adult tissues. Semaphorin receptors, that is plexins and neuropilins, have been found in association with diverse receptor tyrosine kinases (RTKs), such as Met, ErbB2 and VEGFR2. These receptor complexes are formed in a cell-specific manner and can mediate distinctive signalling cascades, sometimes leading to divergent functional outcomes. This is particularly intriguing in cancer, since the same semaphorin has been found to mediate either tumor-promoting or tumor-suppressing functions, depending on the cancer type and cellular context. We will therefore review the current understanding about the role of RTKs in neuropilin and plexin signalling, putatively accounting for the multifaceted role of semaphorins in cancer.
2014
33
40
4795
4802
http://www.nature.com/onc/journal/v33/n40/full/onc2013474a.html
plexin; Neuropilin; met; ErbB2; EGFR; VEGF
G Cagnoni;L Tamagnone
File in questo prodotto:
File Dimensione Formato  
2013_Semaphorin receptors meet receptor tyrosine kinases.pdf

Accesso riservato

Tipo di file: PDF EDITORIALE
Dimensione 1.16 MB
Formato Adobe PDF
1.16 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Cagnoni et al_oncogene_2013.pdf

Open Access dal 03/04/2015

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 629.96 kB
Formato Adobe PDF
629.96 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/150601
Citazioni
  • ???jsp.display-item.citation.pmc??? 24
  • Scopus 43
  • ???jsp.display-item.citation.isi??? 37
social impact