Here we describe a new approach for facilitating a mechanistic understanding of high throughput Caco-2 permeability data. A large, uniform set of permeability data is reported, generated under two pH conditions. It was found that these data could be successfully modelled, and that a mechanistic understanding of apparent permeability could be gained.
Relating Caco-2 permeability to molecular properties using block relevance analysis
ERMONDI, Giuseppe;CARON, Giulia
2015-01-01
Abstract
Here we describe a new approach for facilitating a mechanistic understanding of high throughput Caco-2 permeability data. A large, uniform set of permeability data is reported, generated under two pH conditions. It was found that these data could be successfully modelled, and that a mechanistic understanding of apparent permeability could be gained.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
medchemcomm_rev_final_ConCopertina.pdf
Open Access dal 01/01/2017
Tipo di file:
POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione
1.05 MB
Formato
Adobe PDF
|
1.05 MB | Adobe PDF | Visualizza/Apri |
|
Potter2015RelationCaco-2.pdf
Accesso riservato
Tipo di file:
PDF EDITORIALE
Dimensione
1.02 MB
Formato
Adobe PDF
|
1.02 MB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
