BACKGROUND: Cancer of the larynx in the intermediate/advanced stage still presents a major challenge in terms of controlling the disease and preserving the organ. Among therapeutic options, open partial horizontal laryngectomy (OPHL) is proposed as a function-sparing surgical technique. METHODS: We analyzed the clinical outcomes of 555 patients with laryngeal cancer staged pT3-pT4a who underwent OPHL. RESULTS: 5-year overall survival, disease-free survival, locoregional control, local control, laryngectomy-free survival and laryngeal function preservation rates were 84.6%, 84.2%, 86.3%, 90.6%, 93.3% and 91.2%, respectively. Disease-free survival, locoregional control and laryngeal function preservation rates were significantly affected by pT4a staging (68.1%, 71.7% and 78.0% respectively), while pN+ influenced only disease-free survival (≤72.6%) and locoregional control (≤79.6%). CONCLUSIONS: OPHL with a modular approach can be considered effective in terms of prognostic and functional results in intermediate stage and selected advanced stage laryngeal cancers, even with subglottic extension

Benefits and drawbacks of open partial horizontal laryngectomies, Part B: Intermediate and selected advanced stage laryngeal carcinoma

SUCCO, Giovanni
First
;
CROSETTI, Erika;ARRIGONI, GIULIA;SPRIO, ANDREA ELIO;BERTA, Giovanni Nicolao;
2016

Abstract

BACKGROUND: Cancer of the larynx in the intermediate/advanced stage still presents a major challenge in terms of controlling the disease and preserving the organ. Among therapeutic options, open partial horizontal laryngectomy (OPHL) is proposed as a function-sparing surgical technique. METHODS: We analyzed the clinical outcomes of 555 patients with laryngeal cancer staged pT3-pT4a who underwent OPHL. RESULTS: 5-year overall survival, disease-free survival, locoregional control, local control, laryngectomy-free survival and laryngeal function preservation rates were 84.6%, 84.2%, 86.3%, 90.6%, 93.3% and 91.2%, respectively. Disease-free survival, locoregional control and laryngeal function preservation rates were significantly affected by pT4a staging (68.1%, 71.7% and 78.0% respectively), while pN+ influenced only disease-free survival (≤72.6%) and locoregional control (≤79.6%). CONCLUSIONS: OPHL with a modular approach can be considered effective in terms of prognostic and functional results in intermediate stage and selected advanced stage laryngeal cancers, even with subglottic extension
38
S1
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http://onlinelibrary.wiley.com/doi/10.1002/hed.24064/abstract;jsessionid=8C523E322E3BD97662D3AD681FCE43D1.f04t02
Succo, G; Crosetti, E; Bertolin, A; Lucioni, M; Arrigoni, G; Panetta, V; Sprio, AE; Berta, GN; Rizzotto, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1509086
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