Background. Laryngeal squamous cell carcinoma (SCC) accounts for 1.9% of cancers worldwide. Most of these are diagnosed in the early stages (T1-T2, N0). For these, a larynx preserving/conserving option is preferable. Beyond transoral laser microsurgery (TLM), open partial horizontal laryngectomy (OPHL) is a function-sparing surgical technique used to treat laryngeal SCC. Methods. We retrospectively analyzed the clinical outcomes of 216 patients who underwent OPHL for glottic cT2 laryngeal cancer. Results. Five-year overall survival, disease-specific survival, locoregional control, local control, laryngeal function preservation, and laryngectomy-free survival rates were 93.1%, 98.0%, 97.1%, 97.5%, 97.8% and 98.5%, respectively. Disease controls were significantly affected by previous treatment and type of surgery employed. Conclusions. Although TLM for cT2 laryngeal cancer with unimpaired vocal cord mobility still represents a sound option, OPHL offers higher local control and laryngeal preservation rates for selected patients with impaired mobility of vocal cords combined with involvement of the paraglottic space.

Benefits and drawbacks of open partial horizontal laryngectomies, Part A: Early-intermediate stage glottic carcinoma

SUCCO, Giovanni
First
;
CROSETTI, Erika;CARACCIOLO, ALESSANDRA;SPRIO, ANDREA ELIO;BERTA, Giovanni Nicolao;
2016

Abstract

Background. Laryngeal squamous cell carcinoma (SCC) accounts for 1.9% of cancers worldwide. Most of these are diagnosed in the early stages (T1-T2, N0). For these, a larynx preserving/conserving option is preferable. Beyond transoral laser microsurgery (TLM), open partial horizontal laryngectomy (OPHL) is a function-sparing surgical technique used to treat laryngeal SCC. Methods. We retrospectively analyzed the clinical outcomes of 216 patients who underwent OPHL for glottic cT2 laryngeal cancer. Results. Five-year overall survival, disease-specific survival, locoregional control, local control, laryngeal function preservation, and laryngectomy-free survival rates were 93.1%, 98.0%, 97.1%, 97.5%, 97.8% and 98.5%, respectively. Disease controls were significantly affected by previous treatment and type of surgery employed. Conclusions. Although TLM for cT2 laryngeal cancer with unimpaired vocal cord mobility still represents a sound option, OPHL offers higher local control and laryngeal preservation rates for selected patients with impaired mobility of vocal cords combined with involvement of the paraglottic space.
38
S1
E333
E340
http://onlinelibrary.wiley.com/doi/10.1002/hed.23997/abstract
Open partial laryngectomy; supracricoid partial laryngectomy; supratracheal partial laryngectomy; glottis cancer; laryngeal cancer; TNM staging
Succo, G; Crosetti, E; Bertolin, A; Lucioni, M; Caracciolo, A; Panetta, V; Sprio, AE; Berta, GN; Rizzotto, G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/151933
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