RNA-Seq provides remarkable power in the area of biomarkers discovery and disease characterization. Two crucial steps that affect RNA-Seq experiment results are Library Sample Preparation (LSP) and Bioinformatics Analysis (BA). This work describes an evaluation of the combined effect of LSP methods and BA tools in the detection of splice variants.
Alternative splicing detection workflow needs a careful combination of sample prep and bioinformatics analysis
CARRARA, MATTEO;CORDERO, Francesca;BECCUTI, Marco;DONATELLI, Susanna;CALOGERO, Raffaele Adolfo
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2015-01-01
Abstract
RNA-Seq provides remarkable power in the area of biomarkers discovery and disease characterization. Two crucial steps that affect RNA-Seq experiment results are Library Sample Preparation (LSP) and Bioinformatics Analysis (BA). This work describes an evaluation of the combined effect of LSP methods and BA tools in the detection of splice variants.
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