RNA-Seq provides remarkable power in the area of biomarkers discovery and disease characterization. Two crucial steps that affect RNA-Seq experiment results are Library Sample Preparation (LSP) and Bioinformatics Analysis (BA). This work describes an evaluation of the combined effect of LSP methods and BA tools in the detection of splice variants.
Titolo: | Alternative splicing detection workflow needs a careful combination of sample prep and bioinformatics analysis | |
Autori Riconosciuti: | ||
Autori: | Carrara, Matteo; Lum, Josephine; Cordero, Francesca; Beccuti, Marco; Poidinger, Michael; Donatelli, Susanna; Calogero, Raffaele; Zolezzi, Francesca | |
Data di pubblicazione: | 2015 | |
Abstract: | RNA-Seq provides remarkable power in the area of biomarkers discovery and disease characterization. Two crucial steps that affect RNA-Seq experiment results are Library Sample Preparation (LSP) and Bioinformatics Analysis (BA). This work describes an evaluation of the combined effect of LSP methods and BA tools in the detection of splice variants. | |
Volume: | 16 Suppl 9 | |
Fascicolo: | Suppl 9 | |
Pagina iniziale: | S2 | |
Pagina finale: | S2 | |
Digital Object Identifier (DOI): | 10.1186/1471-2105-16-S9-S2 | |
URL: | http://www.biomedcentral.com/1471-2105/16/S9/S2 | |
Parole Chiave: | Bioinformatics, RNA sequencing | |
Rivista: | BMC BIOINFORMATICS | |
Appare nelle tipologie: | 03A-Articolo su Rivista |
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