HIV patients are exposed to a higher risk of adverse cardiovascular events, due to complex interactions between traditional risk factors and HIV infection itself in terms of ongoing endothelial dysfunctional immune activation/inflammation and increased risk of thrombosis. On the other hand, long-span antiretroviral therapy administration still raises questions on its long-term safety in an era in which life expectancy is becoming longer and longer while treatment of non-HIV-related serious events is increasingly raising concern. In this article, we will critically analyse the current knowledge of pathological and clinical aspects pertaining to the increased risk of cardiovascular events associated with HIV.

Cardiovascular disease in HIV patients: from bench to bedside and backwards

CERRATO, Enrico;CALCAGNO, Andrea
Co-first
;
D'ASCENZO, FABRIZIO;BIONDI ZOCCAI, Giuseppe;GROSSO MARRA, Walter;OMEDE', Pierluigi;BONORA, Stefano;MORETTI, CLAUDIO;GAITA, Fiorenzo
2015-01-01

Abstract

HIV patients are exposed to a higher risk of adverse cardiovascular events, due to complex interactions between traditional risk factors and HIV infection itself in terms of ongoing endothelial dysfunctional immune activation/inflammation and increased risk of thrombosis. On the other hand, long-span antiretroviral therapy administration still raises questions on its long-term safety in an era in which life expectancy is becoming longer and longer while treatment of non-HIV-related serious events is increasingly raising concern. In this article, we will critically analyse the current knowledge of pathological and clinical aspects pertaining to the increased risk of cardiovascular events associated with HIV.
2015
2
1
e000174
e000174
INTERVENTIONAL CARDIOLOGY
Cerrato, Enrico; Calcagno, Andrea; D'Ascenzo, Fabrizio; Biondi-Zoccai, Giuseppe; Mancone, Massimo; Grosso Marra, Walter; Demarie, Daniela; Omedè, Pierluigi; Abbate, Antonio; Bonora, Stefano; Dinicolantonio, James J; Estrada, Vicente; Escaned, Javier; Moretti, Claudio; Gaita, Fiorenzo
File in questo prodotto:
File Dimensione Formato  
CVR review cerrato 2015.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 699.93 kB
Formato Adobe PDF
699.93 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1522180
Citazioni
  • ???jsp.display-item.citation.pmc??? 33
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 63
social impact