The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting the neurogenic strategies used by developing progenitors, the genetic programs involved in cell fate specification, the progressive changes of structural organization, and some of the better-known abnormalities associated with developmental disorders of the cerebellum.

Consensus Paper: Cerebellar Development

LETO, Ketty;BUFFO, Annalisa;PARMIGIANI, ELENA;
2016-01-01

Abstract

The development of the mammalian cerebellum is orchestrated by both cell-autonomous programs and inductive environmental influences. Here, we describe the main processes of cerebellar ontogenesis, highlighting the neurogenic strategies used by developing progenitors, the genetic programs involved in cell fate specification, the progressive changes of structural organization, and some of the better-known abnormalities associated with developmental disorders of the cerebellum.
2016
15
6
789
828
http://link.springer.com/article/10.1007/s12311-015-0724-2/fulltext.html
Cerebellum; Differentiation; Progenitors; Purkinje cells; Specification
Leto, Ketty; Arancillo, Marife; Becker, Esther B. E; Buffo, Annalisa; Chiang, Chin; Ding, Baojin; Dobyns, William B; Dusart, Isabelle; Haldipur, Parth...espandi
File in questo prodotto:
File Dimensione Formato  
Consensus paper short.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 1.51 MB
Formato Adobe PDF
1.51 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1526265
Citazioni
  • ???jsp.display-item.citation.pmc??? 190
  • Scopus 286
  • ???jsp.display-item.citation.isi??? 236
social impact