Antiretroviral pharmacokinetics is defined by numerous factors affecting absorption, distribution, metabolism and elimination. Biological processes underpinning drug distribution are only partially characterized and multiple genetic factors generate cumulative or antagonistic interactions, which complicates the implementation of pharmacogenetic markers. The aim of this study was to assess the degree to which heredity influences pharmacokinetics through the quantification of the relative genetic contribution (rGC) for key antiretrovirals.

Class-specific relative genetic contribution for key antiretroviral drugs

SICCARDI, MARCO;SIMIELE, MARCO;D'AVOLIO, ANTONIO;CALCAGNO, Andrea;DI PERRI, Giovanni;BONORA, Stefano;
2015

Abstract

Antiretroviral pharmacokinetics is defined by numerous factors affecting absorption, distribution, metabolism and elimination. Biological processes underpinning drug distribution are only partially characterized and multiple genetic factors generate cumulative or antagonistic interactions, which complicates the implementation of pharmacogenetic markers. The aim of this study was to assess the degree to which heredity influences pharmacokinetics through the quantification of the relative genetic contribution (rGC) for key antiretrovirals.
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Siccardi, Marco; Olagunju, Adeniyi; Simiele, Marco; D'Avolio, Antonio; Calcagno, Andrea; Di Perri, Giovanni; Bonora, Stefano; Owen, Andrew
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/1528191
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