Catecholamines trigger proximal tubular fluid retention and reduce renal excretion of solute-free water. In advanced cirrhosis, non-osmotic hypersecretion of vasopressin (ADH) is considered the cause of dilutional hyponatremia, but ADH V2 receptor antagonists are not beneficial in long-term treatment of ascites.

Pathogenesis of Solute-Free Water Retention in Experimental Ascitic Cirrhosis: Is Vasopressin the Only Culprit?

ARAGNO, Manuela;MASTROCOLA, Raffaella;PAROLA, Maurizio
Last
2016-01-01

Abstract

Catecholamines trigger proximal tubular fluid retention and reduce renal excretion of solute-free water. In advanced cirrhosis, non-osmotic hypersecretion of vasopressin (ADH) is considered the cause of dilutional hyponatremia, but ADH V2 receptor antagonists are not beneficial in long-term treatment of ascites.
130
117
124
Sansoe', Giovanni; Aragno, Manuela; Mastrocola, Raffaella; Parola, Maurizio
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/1528853
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact