We evaluated the effect of parathyroid hormone (PTH) on Wnt10b production by immune system cells in humans. We showed that bone anabolic effect of intermittent PTH treatment may be amplified by T cells through increased production of Wnt10b. Chronic increase in PTH as in primary hyperparathyroidism does not increase Wnt10b expression.
Treatment with intermittent PTH increases Wnt10b production by T cells in osteoporotic patients
D'AMELIO, Patrizia
First
;Sassi, F;BUONDONNO, ILARIA;FORNELLI, Giorgia;SPERTINO, Elena;D'AMICO, LUCIA;ROATO, ILARIA;ISAIA, Giovanni Carlo
2015-01-01
Abstract
We evaluated the effect of parathyroid hormone (PTH) on Wnt10b production by immune system cells in humans. We showed that bone anabolic effect of intermittent PTH treatment may be amplified by T cells through increased production of Wnt10b. Chronic increase in PTH as in primary hyperparathyroidism does not increase Wnt10b expression.
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