In the adult brain, subsets of astrocytic cells residing in well-defined neurogenic niches constitutively generate neurons throughout life. Brain lesions can stimulate neurogenesis in otherwise non-neurogenic regions, but whether local astrocytic cells generate neurons in these conditions is unresolved. Here, through genetic and viral lineage tracing in mice, we demonstrate that striatal astrocytes become neurogenic following an acute excitotoxic lesion. Similar to astrocytes of adult germinal niches, these activated parenchymal progenitors express nestin and generate neurons through the formation of transit amplifying progenitors. These results shed new light on the neurogenic potential of the adult brain parenchyma.

Striatal astrocytes produce neuroblasts in an exicitotoxic model of Huntington's disease.

NATO, GIULIA;TROVA, SARA;Avataneo V.;BUFFO, Annalisa;PERETTO, Paolo Marcello;LUZZATI, FEDERICO
2015

Abstract

In the adult brain, subsets of astrocytic cells residing in well-defined neurogenic niches constitutively generate neurons throughout life. Brain lesions can stimulate neurogenesis in otherwise non-neurogenic regions, but whether local astrocytic cells generate neurons in these conditions is unresolved. Here, through genetic and viral lineage tracing in mice, we demonstrate that striatal astrocytes become neurogenic following an acute excitotoxic lesion. Similar to astrocytes of adult germinal niches, these activated parenchymal progenitors express nestin and generate neurons through the formation of transit amplifying progenitors. These results shed new light on the neurogenic potential of the adult brain parenchyma.
DEVELOPMENT
142
5
840
845
https://journals.biologists.com/dev/article/142/5/840/47197/Striatal-astrocytes-produce-neuroblasts-in-an
Huntington’sdisease; Lesion-inducedneurogenesis; Mouse; Neural stemcells; Parenchymal progenitors; Stemcell quiescence
1. Nato G.; Caramello A.; Trova S.; Avataneo V.; Rolando C.; Taylor V.; Buffo A.; Peretto P.; Luzzati F.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/153280
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